• PureChain Labs ARA-290
1 1

ARA-290

ARA-290

$70.00
$70.00 $110.00
SAVE 36% Sold out

ARA-290

$70.00
$70.00 $110.00
SAVE 36% Sold out

Get it as soon as -

30 Day Trial

We're confident you'll be happy with your order! In case things don't go as planned, you have 30 days to request a refund based on our return and refund policy.

Shipping & Processing

Our shipping services are designed to be fast and reliable, ensuring your order is delivered promptly. Please allow 5-10 business days for delivery.

Track My Order

Once your order is shipped, we will provide you with a tracking number to monitor the progress of your shipment on our website or the shipping carrier's website. You can track your order here Track My Order

Each vial contains 10mg of highly pure ARA-290.

ARA-290 is a synthetic peptide derived from the tertiary structure of erythropoietin (EPO), specifically engineered to retain its tissue-protective and anti-inflammatory properties while avoiding the erythropoietic (red blood cell–stimulating) effects associated with full-length EPO. It is primarily studied for its role in modulating innate repair pathways, reducing inflammation, and promoting cellular resilience in damaged or stressed tissues.

This peptide functions by selectively binding to the innate repair receptor (IRR), a heteromeric receptor complex distinct from the classical EPO receptor responsible for red blood cell production. Activation of this pathway initiates a cascade of anti-inflammatory and cytoprotective signals, helping to reduce pro-inflammatory cytokine activity while supporting tissue repair and regeneration.

By engaging IRR signaling, ARA-290 has demonstrated the ability to attenuate inflammatory responses and protect against cellular injury in preclinical models. These effects are associated with improved nerve function, reduced neuropathic discomfort, and enhanced recovery in models of metabolic and inflammatory stress. Its mechanism supports restoration of normal cellular function without altering hematocrit or oxygen-carrying capacity.

Unlike traditional EPO-based compounds, ARA-290 is designed to act exclusively on tissue-protective pathways, allowing for more targeted investigation of inflammation and repair mechanisms without the risks linked to increased erythropoiesis. This selectivity makes it particularly valuable in research settings focused on chronic inflammation, neuropathy, and tissue injury.

In addition to its anti-inflammatory effects, ARA-290 has shown potential in supporting small fiber nerve regeneration and improving microvascular function. These properties make it a subject of interest in studies exploring complications related to metabolic disorders, including nerve damage and impaired tissue healing.

ARA-290 is primarily utilized in laboratory and experimental research to study inflammation modulation, neuropathic pathways, and tissue repair signaling. Ongoing investigations continue to explore its long-term safety profile and broader therapeutic potential across inflammatory and degenerative conditions.

Key Points

Action:
Activates the innate repair receptor to reduce inflammation, protect against cellular damage, and promote tissue repair without stimulating red blood cell production.

Indications:
Used in research related to neuropathy, chronic inflammation, tissue injury, metabolic dysfunction, and nerve regeneration.

Difference from Erythropoietin-Based Compounds:
ARA-290 selectively targets tissue-protective signaling pathways derived from erythropoietin while avoiding erythropoietic activity, offering a more focused approach to studying inflammation and repair mechanisms without affecting hematological parameters.


Add 1mL of bacteriostatic water to get a solution that is 10mg/mL, such that every 0.1mL (10 units on an insulin syringe) is equal to 1mg of ARA-290.

This product must be refrigerated after reconstitution.
View full details

01The PureChain Standard

Purity And Documentation

Your results are only as good as the compound you start with.

Every vial is labelled with its compound, vial size and molecular weight, and ships for laboratory research use only. Third-party testing details will be published here.

Supplied for in-vitro laboratory research only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.

Size
10mg
Form
Lyophilized powder
Storage
−20 °C, protected from light
Molar mass
1257.3 Da

About This Compound

About ARA-290

ARA-290, also called cibinetide, is an 11-amino-acid peptide taken from a helical region of erythropoietin. Erythropoietin has two separate jobs: it drives red blood cell production through the classical EPO receptor homodimer, and it protects tissue through a different receptor – the innate repair receptor, a heterocomplex of EPOR and the beta common receptor CD131. ARA-290 was designed to engage the second without the first, which makes it the standard tool for studying tissue-protective EPO signalling separated from erythropoiesis.

Non-Erythropoietic Erythropoietin-Derived Peptide

Molecular Formula

C51H84N16O21

Molecular Weight

1257.3 g/mol

Form

Lyophilized Powder

CAS Number

1208243-50-8

02Molecular Structure

The ARA-290 molecule

An illustrative atomic representation generated from the compound record, alongside its verified molecular data. The structure figure is schematic – not a measured conformation.

  • C
  • H
  • N
  • O
  • S/P
Molecular Formula C51H84N16O21
Molecular Weight 1257.3 g/mol
Sequence Length 11 residues
Chemical Name Cibinetide (ARA-290)
Physical Form Lyophilized Powder
CAS Number 1208243-50-8
Use Class Research use only

Molecular data from the public PubChem record (CID 91810664). View on PubChem

By The Numbers

ARA-290 Research, By The Numbers

The figures that define ARA-290 and how it is being studied. For laboratory research use only.

11

Amino Acids

Derived from helix B of the erythropoietin molecule

IRR

Receptor Target

The innate repair receptor: an EPOR / CD131 heterocomplex

None

Erythropoietic Activity

Designed not to engage the classical EPO receptor homodimer

4

Research Areas

  • Innate Repair Receptor Signalling
  • Neuropathy Models
  • Tissue-Protection Studies
  • Inflammation Research

How It Works

How ARA-290 Works

The pathways ARA-290 acts on, and what each one does. Described from preclinical and receptor-pharmacology literature.

IRR Engagement

The Second Erythropoietin Receptor

The innate repair receptor is a heterocomplex of the erythropoietin receptor with the beta common receptor CD131. It mediates the tissue-protective side of erythropoietin signalling and is distinct from the EPOR homodimer that drives red cell production.

  • Binds the EPOR / CD131 heterocomplex
  • Distinct from the erythropoietic EPOR homodimer
  • The tissue-protective arm of EPO signalling
Non-Erythropoietic Design

Separating The Two Functions

The whole purpose of the molecule is subtraction. By taking only helix B, ARA-290 keeps the repair signalling while dropping the haematopoietic activity, so preclinical studies avoid the confound of a rising haematocrit.

  • No stimulation of red blood cell production reported
  • Avoids the haematocrit confound in tissue studies
  • A designed separation of two receptor pathways
Inflammatory Modulation

Small Fibre And Neuropathy Models

Most of the published work on ARA-290 sits in small-fibre neuropathy and inflammatory tissue models, where the innate repair receptor pathway is investigated for its effect on nerve fibre density and on local inflammatory signalling.

  • Studied in small-fibre neuropathy models
  • Nerve fibre density is a common measured endpoint
  • Investigated alongside local inflammatory markers

Signalling pathways studied in preclinical models. Illustrative, not a claim of effect in humans.

Uses And Applications

What ARA-290 Is Researched For

The main areas ARA-290 is studied in, and the qualitative magnitudes reported alongside them.

Innate Repair Receptor Signalling

The defining use: characterising the EPOR / CD131 heterocomplex and what it does when engaged without the erythropoietic receptor.

Neuropathy Models

The largest published research area for the peptide, concentrated on small-fibre neuropathy and nerve fibre density endpoints.

Tissue-Protection Studies

Applied in ischaemia and injury models investigating whether the protective arm of EPO signalling can be engaged on its own.

Inflammation Research

Used to study local inflammatory signalling in tissue where the innate repair receptor is expressed.

Study-Reported Magnitudes

Qualitative summaries of published research. Bars fill as you scroll.

Innate Repair Receptor Engagement By Design
Erythropoietic Activity Absent By Design
Neuropathy Model Literature Substantial
Selectivity Versus Full-Length EPO High

Figures are representative summaries of published research findings, shown for reference only. They are not claims about outcomes in humans.

Compound Information

Full Specification

Chemical Name Cibinetide (ARA-290)
Molecular Weight 1257.3 Da
Molecular Formula C51H84N16O21
CAS Number 1208243-50-8
Form Lyophilized powder
Solubility Water-soluble
Storage Store lyophilized at −20 °C, protected from light and moisture
Vial Size 10mg
PubChem CID 91810664

FAQ

Common Questions About ARA-290

What Is ARA-290?

An 11-amino-acid peptide derived from helix B of erythropoietin, also known as cibinetide. It is supplied here as a research compound.

Does ARA-290 Raise Red Blood Cell Counts?

It is specifically designed not to. ARA-290 engages the innate repair receptor rather than the classical erythropoietin receptor homodimer, and no erythropoietic activity is reported for it.

What Is The Innate Repair Receptor?

A heterocomplex of the erythropoietin receptor and the beta common receptor CD131. It carries the tissue-protective side of erythropoietin signalling, separately from red cell production.

Why Take Only Part Of Erythropoietin?

To separate two functions that the full molecule performs together. Using only helix B keeps the repair signalling and removes the haematopoietic activity, which would otherwise confound tissue studies.

Is ARA-290 Approved For Human Use?

No. It is supplied as a research chemical for in-vitro laboratory work only.

How Should Research-Grade ARA-290 Be Stored?

Store the lyophilized powder at −20 °C, protected from light and moisture, and refrigerate once reconstituted. Aliquot rather than repeatedly freezing and thawing a single vial.

Feedback

WHAT OUR CUSTOMERS HAVE TO SAY...

"Been using PureChain Labs for 9 months now. In my opinion, it's the best source in Canada. Quality product every time and gives me the best results. Also the communication is second to none, I get a response in minutes usually. Overall extremely happy with the service and product they provide."
Mike C.
"A+ service and communication. Delivery is always quick and packaged safe and sound... I love how they are transparent and you know what your getting and for using a new source for the first time that's a huge relief."
Jennifer M.
"Took a month but hair felt thicker at roots, gave me hope after months of thinning, they definitely sell quality peptides."
Melissa P.
Research Use Only

Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA or Health Canada; this product is not intended to diagnose, treat, cure or prevent any disease.