Melanotan-1
Melanotan-1
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Melanotan-1
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Each vial contains 10mg of lyophilized Melanotan-1.
Melanotan-1 (afamelanotide) is a synthetic version of alpha-MSH that mainly activates the MC1 receptor, which controls melanin production in pigment cells. Researchers use it to study pigmentation and how melanin production is regulated.
01The PureChain Standard
Purity And Documentation
Your results are only as good as the compound you start with.
Every vial is labelled with its compound, vial size and molecular weight, and ships for laboratory research use only. Third-party testing details will be published here.
Supplied for in-vitro laboratory research only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
- Size
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- Molar mass
- 1646.8 Da
About This Compound
About Melanotan-1
Melanotan-1, known by the international nonproprietary name afamelanotide, is a synthetic analogue of alpha-melanocyte-stimulating hormone. It keeps the full 13-residue length of the natural hormone and changes exactly two positions: methionine at position 4 becomes norleucine, and the L-phenylalanine at position 7 becomes its D-enantiomer. Both substitutions target the same weakness - native alpha-MSH is taken apart by peptidases within minutes - and together they give a molecule that survives long enough to be useful as a laboratory tool. It is worth reading alongside Melanotan-2, which solves the same stability problem a different way: MT-2 is a shortened CYCLIC peptide, where MT-1 stays linear and full-length. That structural split is the reason the two are studied for different things. PureChain Labs supplies Melanotan-1 as a lyophilised powder for in-vitro laboratory research only.
Linear Alpha-MSH Analogue
Molecular Formula
Molecular Weight
Form
CAS Number
02Molecular Structure
The Melanotan-1 molecule
An illustrative atomic representation generated from the compound record, alongside its verified molecular data. The structure figure is schematic – not a measured conformation.
- C
- H
- N
- O
- S/P
Molecular data from the public PubChem record (CID 16197727). View on PubChem
By The Numbers
Melanotan-1 Research, By The Numbers
The figures that define Melanotan-1 and how it is being studied. For laboratory research use only.
Amino Acids
Full alpha-MSH length, unlike the 7-residue cyclic MT-2
Backbone
No lactam bridge - the structural opposite of Melanotan-2
Molecular Weight (g/mol)
C78H111N21O19, PubChem CID 16197727
Research Areas
- Melanocortin Receptor Pharmacology
- Melanogenesis Studies
- Peptide Stability Research
- Structure-Activity Comparison
How It Works
How Melanotan-1 Works
The pathways Melanotan-1 acts on, and what each one does. Described from preclinical and receptor-pharmacology literature.
Nle4 And D-Phe7
Native alpha-MSH is degraded rapidly by peptidases. Replacing Met4 with norleucine removes the oxidation-prone sulfur, and inverting Phe7 to the D-form puts a bond that proteases are not shaped to cut into the middle of the recognition sequence. Published work reports the pair together produce a markedly longer-lived and more potent analogue than the parent hormone.
- Met4 to norleucine removes an oxidisable sulfur
- D-Phe7 resists proteolytic cleavage
- Reported as more potent and longer-lived than alpha-MSH
Where The Selectivity Differs
The melanocortin family runs MC1R through MC5R. MT-1 is described in the literature as relatively selective for MC1R, the receptor expressed on melanocytes. MT-2 is reported as broadly non-selective across the family, which is why the two peptides are not interchangeable in a study design even though they share an ancestor.
- MC1R is the melanocyte receptor
- MT-1 reported as relatively MC1R-selective
- MT-2 reported as non-selective across MC1R-MC5R
The Measured Endpoint
MC1R activation on melanocytes drives the pathway that shifts pigment synthesis toward eumelanin. In research settings this is measured directly - melanin content in cultured melanocytes, tyrosinase activity, receptor binding - rather than inferred.
- MC1R signalling favours eumelanin synthesis
- Melanin content and tyrosinase activity are the readouts
- Findings are specific to the model used
Uses And Applications
What Melanotan-1 Is Researched For
The main areas Melanotan-1 is studied in, and the qualitative magnitudes reported alongside them.
Melanocortin Receptor Pharmacology
The primary research use. MT-1 is a standard reference ligand in binding and functional assays across the MC1R-MC5R family.
Melanogenesis Studies
Applied in cultured melanocyte work where melanin content and tyrosinase activity are the measured endpoints.
Peptide Stability Research
The Nle4/D-Phe7 pair is a textbook worked example of stabilising a linear peptide without cyclising it, and is studied as a design strategy in its own right.
Structure-Activity Comparison
Run directly against Melanotan-2 to separate what follows from receptor selectivity and what follows from the linear-versus-cyclic backbone.
Compound Information
Full Specification
| Chemical Name | Afamelanotide (Melanotan-1) |
|---|---|
| Sequence | Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2 |
| Molecular Weight | 1646.8 Da |
| Molecular Formula | C78H111N21O19 |
| CAS Number | 75921-69-6 |
| Form | Lyophilized powder |
| Solubility | Water-soluble |
| Storage | Store lyophilized at −20 °C, protected from light and moisture |
| Vial Size | 10mg |
| PubChem CID | 16197727 |
FAQ
Common Questions About Melanotan-1
What Is Melanotan-1?
A synthetic 13-residue analogue of alpha-melanocyte-stimulating hormone, also known as afamelanotide. PubChem lists it under CID 16197727 with the formula C78H111N21O19, a molecular weight of 1646.8 g/mol and CAS number 75921-69-6.
How Is It Different From Melanotan-2?
They are different molecules, not two grades of one. Melanotan-1 is linear and keeps all 13 residues of the parent hormone; Melanotan-2 is a shortened seven-residue peptide closed into a ring by a lactam bridge. The literature describes MT-1 as relatively selective for MC1R and MT-2 as non-selective across the melanocortin family.
What Do Nle4 And D-Phe7 Mean?
They are the two positions where MT-1 differs from natural alpha-MSH. Position 4 carries norleucine instead of methionine, and position 7 carries D-phenylalanine instead of the L-form. Both changes are there to slow enzymatic degradation.
What Is MC1R?
Melanocortin 1 receptor, expressed on melanocytes. Its activation drives the signalling pathway associated with eumelanin synthesis, which is the endpoint most often measured in melanogenesis research.
Is Melanotan-1 Approved For Human Use?
Nothing supplied by PureChain Labs is approved for human use or sold for it. Afamelanotide exists as a prescription medicine in some jurisdictions for a rare inherited condition; that has no bearing on this material, which is supplied as a research chemical for in-vitro laboratory work only.
How Should Research-Grade Melanotan-1 Be Stored?
As supplied it is a lyophilised powder; the vial directs storage in a cool, dry place in the lyophilised state, and refrigeration once reconstituted.
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Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA or Health Canada; this product is not intended to diagnose, treat, cure or prevent any disease.