CJC-1295 No DAC
CJC-1295 No DAC
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CJC-1295 No DAC
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CJC-1295 No DAC (also known as Modified GRF 1-29) is a synthetic peptide analog of Growth Hormone-Releasing Hormone (GHRH) that stimulates the pituitary gland to release growth hormone. Unlike the DAC version, it has a short half-life (approx. 30–120 min), promoting a natural, pulsatile release of growth hormone ideal for research on recovery and muscle growth.
01The PureChain Standard
Purity And Documentation
Your results are only as good as the compound you start with.
Every vial is labelled with its compound, vial size and molecular weight, and ships for laboratory research use only. Third-party testing details will be published here.
Supplied for in-vitro laboratory research only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
- Size
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- Molar mass
- 3367.9 Da
About This Compound
About CJC-1295 No DAC
CJC-1295 without DAC – also called modified GRF(1-29) – is a 29-residue fragment of growth hormone-releasing hormone carrying four amino acid substitutions that make it resistant to enzymatic breakdown. The name is confusing, and the confusion matters: the original CJC-1295 carries a Drug Affinity Complex, a maleimide group that binds serum albumin and stretches its half-life to days. Remove the DAC and you keep the substitutions but lose the albumin anchor, leaving a short-acting analog. The two are chemically different molecules with different masses, so the figures here come from PubChem’s separate entry for the no-DAC form – listed as "CJC1295 Without DAC" – never from its "CJC-1295" record, which is the DAC version.
Short-Acting GHRH(1-29) Analog
Molecular Formula
Molecular Weight
Form
CAS Number
02Molecular Structure
The CJC-1295 No DAC molecule
An illustrative atomic representation generated from the compound record, alongside its verified molecular data. The structure figure is schematic – not a measured conformation.
- C
- H
- N
- O
- S/P
Molecular data from the public PubChem record (CID 91976842). View on PubChem
By The Numbers
CJC-1295 No DAC Research, By The Numbers
The figures that define CJC-1295 No DAC and how it is being studied. For laboratory research use only.
Amino Acids
The GHRH(1-29) fragment, the shortest fully active portion of the hormone
Substitutions
D-Ala², Gln⁸, Ala¹⁵ and Leu²⁷
The Defining Difference
No albumin-binding Drug Affinity Complex, so short-acting
Research Areas
- GH Secretion Studies
- Pulsatile Release Models
- Peptide Half-Life Design
- GHRH Receptor Pharmacology
How It Works
How CJC-1295 No DAC Works
The pathways CJC-1295 No DAC acts on, and what each one does. Described from preclinical and receptor-pharmacology literature.
Driving The Pituitary
The peptide binds the growth hormone-releasing hormone receptor on pituitary somatotrophs and stimulates release of endogenous growth hormone. GHRH(1-29) is the shortest fragment that retains full activity, which is why every analog in this family is built on it.
- Agonist at the pituitary GHRH receptor
- GHRH(1-29) is the minimal fully active fragment
- Stimulates endogenous rather than exogenous GH
Resistance Without An Anchor
D-Ala at position 2 blocks DPP-4 cleavage; Gln8 removes an asparagine deamidation site; Ala15 and Leu27 further stabilise the sequence. Together they extend the peptide’s survival without attaching it to anything.
- D-Ala² blocks dipeptidyl peptidase-4
- Gln⁸ removes a deamidation site
- Ala¹⁵ and Leu²⁷ add further stability
Why Removing The DAC Changes The Experiment
With the Drug Affinity Complex, CJC-1295 binds albumin and persists for days, producing a sustained elevation. Without it, the analog acts over a much shorter window, so models using it retain the pulsatile secretion pattern rather than flattening it.
- No albumin binding, so no multi-day persistence
- Preserves pulsatile rather than continuous release
- Chosen when the pulse pattern is the variable
Uses And Applications
What CJC-1295 No DAC Is Researched For
The main areas CJC-1295 No DAC is studied in, and the qualitative magnitudes reported alongside them.
Growth Hormone Secretion Studies
The core use: measuring the pituitary GH response to GHRH receptor agonism over a short window.
Pulsatile Release Models
Preferred over the DAC version wherever the pulse structure of secretion, not the total amount, is the subject of the experiment.
Peptide Half-Life Design
A clean comparison against the DAC version for how much an albumin anchor changes a peptide’s pharmacokinetics, with the sequence held constant.
GHRH Receptor Pharmacology
Studied alongside sermorelin and tesamorelin to compare fragment length and stabilisation strategy across the GHRH analog family.
Compound Information
Full Specification
| Chemical Name | CJC-1295 without DAC (modified GRF 1-29) |
|---|---|
| Molecular Weight | 3367.9 Da |
| Molecular Formula | C152H252N44O42 |
| CAS Number | 863288-34-0 |
| Form | Lyophilized powder |
| Solubility | Water-soluble |
| Storage | Store lyophilized at −20 °C, protected from light and moisture |
| Vial Size | 10mg |
| PubChem CID | 91976842 |
FAQ
Common Questions About CJC-1295 No DAC
What Is CJC-1295 No DAC?
A 29-amino-acid GHRH analog, also called modified GRF(1-29), with four stabilising amino acid substitutions and no albumin-binding complex. It is supplied here as a research compound.
What Is DAC, And What Changes Without It?
DAC is a Drug Affinity Complex – a maleimide group that binds serum albumin and extends the peptide’s half-life to days. Without it the analog is short-acting, so growth hormone release stays pulsatile instead of being sustained.
Which PubChem Record Applies To This Product?
The one listed as "CJC1295 Without DAC". PubChem’s "CJC-1295" record is the DAC version – a different molecule with a different mass – and its "Sermorelin" record is a different peptide again. Neither applies here. The CAS shown, 863288-34-0, is the acetate salt, which is also what the vial label prints.
How Does It Differ From Sermorelin?
Sermorelin is the unmodified GHRH(1-29) fragment. This analog is the same 29 residues with four substitutions that slow its degradation.
Is CJC-1295 No DAC Approved For Human Use?
No. It is supplied as a research chemical for in-vitro laboratory work only.
How Should It Be Stored?
Store the lyophilized powder at −20 °C, protected from light and moisture, and refrigerate after reconstitution.
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Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA or Health Canada; this product is not intended to diagnose, treat, cure or prevent any disease.