SEMAX
SEMAX
Couldn't load pickup availability
SEMAX
Get it as soon as -
30 Day Trial
30 Day Trial
We're confident you'll be happy with your order! In case things don't go as planned, you have 30 days to request a refund based on our return and refund policy.
Shipping & Processing
Shipping & Processing
Our shipping services are designed to be fast and reliable, ensuring your order is delivered promptly. Please allow 5-10 business days for delivery.
Track My Order
Track My Order
Once your order is shipped, we will provide you with a tracking number to monitor the progress of your shipment on our website or the shipping carrier's website. You can track your order here Track My Order
Each vial contains 10mg of highly pure Semax in lyophilized form. Please note this batch is overdosed to ~13mg per vial, per the Janoshik test report.
Semax is a synthetic peptide derived from the adrenocorticotropic hormone (ACTH) fragment (Met-Glu-His-Phe-Pro-Gly-Pro). Originally developed in Russia, Semax has been widely studied for its potential nootropic, neuroprotective, and neurorestorative properties.
Research Applications:
-
Investigation of neuroplasticity and cognitive enhancement mechanisms
-
Studies on neuroprotection in models of ischemia and brain injury
-
Exploration of mood regulation and stress response pathways
01The PureChain Standard
Purity And Documentation
Your results are only as good as the compound you start with.
Every vial is labelled with its compound, vial size and molecular weight, and ships for laboratory research use only. Third-party testing details will be published here.
Supplied for in-vitro laboratory research only. Not for human or veterinary use, and not intended to diagnose, treat, cure or prevent any disease.
- Size
- 10mg
- Form
- Lyophilized powder
- Storage
- −20 °C, protected from light
- Molar mass
- 813.9 Da
About This Compound
About SEMAX
Semax is a synthetic heptapeptide built from the ACTH(4-10) fragment with a Pro-Gly-Pro tail added at the C-terminus. The parent fragment has no corticotropic activity – it does not stimulate the adrenal cortex – which is precisely why it was chosen: it isolates the behavioural and neurotrophic side of melanocortin signalling from the hormonal side. The proline-rich tail protects the peptide from aminopeptidase cleavage, and the molecule is one of the most studied nootropic peptides in the Russian-language neuropharmacology literature.
Synthetic ACTH(4-10) Heptapeptide Analog
Molecular Formula
Molecular Weight
Form
CAS Number
02Molecular Structure
The SEMAX molecule
An illustrative atomic representation generated from the compound record, alongside its verified molecular data. The structure figure is schematic – not a measured conformation.
- C
- H
- N
- O
- S/P
Molecular data from the public PubChem record (CID 9811102). View on PubChem
By The Numbers
SEMAX Research, By The Numbers
The figures that define SEMAX and how it is being studied. For laboratory research use only.
Amino Acids
ACTH(4-10) with a C-terminal Pro-Gly-Pro extension
Corticotropic Activity
The ACTH(4-10) fragment does not stimulate the adrenal cortex
Stabilising Motif
The proline-rich tail resists aminopeptidase degradation
Research Areas
- Neurotrophic Factor Expression
- Cognitive Function Models
- Neuroprotection Studies
- Melanocortin Neuropharmacology
How It Works
How SEMAX Works
The pathways SEMAX acts on, and what each one does. Described from preclinical and receptor-pharmacology literature.
BDNF And NGF Signalling
Published work reports that Semax increases the expression of brain-derived neurotrophic factor and nerve growth factor, along with their receptors, in central nervous system tissue. That neurotrophic axis is the most frequently cited mechanism in the literature on the peptide.
- Reported increases in BDNF and NGF expression
- Effects described on the corresponding receptors
- Measured in hippocampal and cortical tissue models
Behaviour Without The Hormone
ACTH(4-10) is the behaviourally active core of adrenocorticotropic hormone, separated from the part that drives cortisol release. Working with the fragment lets researchers study melanocortin effects on learning and attention without confounding them with an endocrine stress response.
- Derived from the ACTH(4-10) core fragment
- No adrenal stimulation, so no cortisol confound
- Used to separate behavioural from hormonal melanocortin effects
Why The Pro-Gly-Pro Tail Is There
Short linear peptides are cleaved rapidly by aminopeptidases. The C-terminal Pro-Gly-Pro sequence sharply slows that degradation, which is what makes an otherwise fragile seven-residue peptide practical as a research tool.
- Proline residues resist aminopeptidase cleavage
- A different stabilisation strategy to cyclisation
- Comparable in intent to tesamorelin’s N-terminal acylation
Uses And Applications
What SEMAX Is Researched For
The main areas SEMAX is studied in, and the qualitative magnitudes reported alongside them.
Neurotrophic Factor Expression
The central research use: measuring BDNF and NGF expression and receptor response in central nervous system tissue models.
Cognitive Function Models
Applied in preclinical learning, memory and attention paradigms, where the absence of a cortisol response is a methodological advantage.
Neuroprotection Studies
Used in ischaemia and oxidative-stress models investigating whether neurotrophic signalling changes the outcome for exposed neurons.
Melanocortin Neuropharmacology
Studied as the fragment that separates the behavioural arm of melanocortin signalling from the hypothalamic-pituitary-adrenal arm.
Compound Information
Full Specification
| Chemical Name | Semax (Met-Glu-His-Phe-Pro-Gly-Pro) |
|---|---|
| Sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Molecular Weight | 813.9 Da |
| Molecular Formula | C37H51N9O10S |
| CAS Number | 80714-61-0 |
| Form | Lyophilized powder |
| Solubility | Water-soluble |
| Storage | Store lyophilized at −20 °C, protected from light and moisture |
| Vial Size | 10mg |
| PubChem CID | 9811102 |
FAQ
Common Questions About SEMAX
What Is Semax?
A synthetic heptapeptide consisting of the ACTH(4-10) fragment with a Pro-Gly-Pro tail added at the C-terminus. It is supplied here as a research compound.
Does Semax Affect Cortisol?
The ACTH(4-10) fragment it is built from has no corticotropic activity – it does not stimulate the adrenal cortex. That separation is the reason the fragment was chosen.
What Does The Pro-Gly-Pro Tail Do?
It protects the peptide from aminopeptidase cleavage. Without it, a short linear heptapeptide would be degraded too quickly to be a practical research tool.
What Is BDNF And Why Does It Come Up?
Brain-derived neurotrophic factor is a protein that supports neuron survival and synaptic plasticity. Reported increases in its expression are the most frequently cited mechanism in the Semax literature.
Is Semax Approved For Human Use?
The material supplied here is a research chemical for in-vitro laboratory use only. Regulatory status in any other jurisdiction does not change what this product is supplied as.
How Should Research-Grade Semax Be Stored?
Store the lyophilized powder at −20 °C, protected from light and moisture, and refrigerate after reconstitution. The methionine residue at the N-terminus is oxidation-prone, so keep solutions cold and avoid prolonged air exposure.
Feedback
WHAT OUR CUSTOMERS HAVE TO SAY...
"Been using PureChain Labs for 9 months now. In my opinion, it's the best source in Canada. Quality product every time and gives me the best results. Also the communication is second to none, I get a response in minutes usually. Overall extremely happy with the service and product they provide."
"A+ service and communication. Delivery is always quick and packaged safe and sound... I love how they are transparent and you know what your getting and for using a new source for the first time that's a huge relief."
"Took a month but hair felt thicker at roots, gave me hope after months of thinning, they definitely sell quality peptides."
Not for human or veterinary use. For in-vitro laboratory research only. These statements have not been evaluated by the FDA or Health Canada; this product is not intended to diagnose, treat, cure or prevent any disease.